Author/Authors :
Salman، Suleyman نويسنده Obstetrics and Gynecology Hospital, Ministry of Health, Igd?r, Turkey , , Kumbasar، Serkan نويسنده Ministry of Health, Obstetrics and Gynecology Hospital, Igdir, Turkey , , Gursan، Nesrin نويسنده Department of Pathology, Ataturk University Medical Faculty, 25240 Erzurum, Turkey , , Kumtepe، Yakup نويسنده Obstetrics and Gynecology Department, Faculty of Medicine, Atatürk University, Erzurum, Turkey , , Borekci، Bunyamin نويسنده Obstetrics and Gynecology Department, Faculty of Medicine, Atatürk University, Erzurum, Turkey , , Polat، Beyzagul نويسنده Department of Pharmacology, Ataturk University Medical Faculty, 25240 Erzurum, Turkey , , Hakan Alp، Hamit نويسنده Department of Biochemistry, Ataturk University Medical Faculty, 25240 Erzurum, Turkey , , Talip Sener، Mustafa نويسنده Department of Forensic Medicine, Ataturk University Medical Faculty, 25240 Erzurum, Turkey , , Suleyman، Halis نويسنده Pharmacology Department, Faculty of Medicine, Atatürk University, Erzurum, Turkey ,
Abstract :
Background:In this study, we investigated the effects of treatment with chronic antihypertensive drugs (clonidine, methyldopa, amlodipine, ramipril and rilmenidine) on oxidant-antioxidant
parameters and toxic effects on DNA in rat uterus tissue. In addition, uterus tissues were examined
histopathologically.
Materials and Methods: A total of 36 albino Wistar rats were divided into the following six groups:
0.075 mg/kg clonidine group; 100 mg/kg methyldopa group; 2 mg/kg amlodipine group; 2.5 mg/kg ramipril group; 0.5 mg/kg rilmenidine group; and the healthy group. Rats underwent chronic drug administration for 30 days and at the end, biochemical and histopathological examinations were performed. All data were subjected to one-way ANOVA test.
Results: We divided these drugs into the following three groups according to their effects on rat uteri: (I) mild negative effects (clonidine), (II) moderate negative effects (rilmenidine, methyldopa) and (III) drugs which had severe negative effects (amlodipine, ramipril).
Conclusion: These data may help with selection of antihypertensive drugs, in order to determine which drugs have the lowest toxicity in pregnant and non-pregnant (pre-pregnancy) women.
