Suicidal Attempt in Bipolar Disorder: Low Significance of Comorbidity with Opioid Dependence

Objectives: The relationship between suicidal attempt and opioid use disorder in patients with bipolar disorder (BD) is unknown. This study aimed at shedding some light on this issue. Method: 176 inpatients aged 18-65 with BD type I with or without opioid use disorders were interviewed face-to-face through the Persian Structured Clinical Interview for DSM-IV axis I disorders (SCID-I), the Global Assessment of Functioning (GAF) scale, and a questionnaire including demographic characteristics and some clinical factors . Results: Gender was the only demographic factor with a statistically significant difference between suicidal and non-suicidal bipolar patients. In addition, comorbidity with anxiety disorders and the type of index and current mood episodes were significantly different between the two groups (p<0.05). However, after using a logistic regression analysis, the only statistically significant different factors (p<0.05) between the two groups were gender, comorbidity with anxiety disorders, and GAF . Conclusion: Opioid dependence comorbidity can not be considered as a risk factor for suicidal attempt in patients with BD.