Antifertility activity of the aqueous leaf extract of Cissampelos pareira in male albino mice

Aqueous leaf extract of Cissampelos pareira (L) Hirsuta (family Menispermaceae) was evaluated for the validity of the anti-fertility effect in male mice after oral administration with the extract at dose of 0.5 and 1.0 ml/ 100 gBW daily for 14 days. The significant increment of plasma prolactin and depletion of follicle stimulating hormone (FSH) in the high dose treated group were found (p<0.05). Interestingly results, the depletion of seminal testicular weight was presented in both treated groups whereas seminal quality impairment including a decrease in total sperm count and a increase in percentage of abnormal sperms were shown in the high dose treated group only. The results indicated the infertility effect of aqueous Cissampelos pareira leaf extract in male mice occurring after high dose of extract intake by causing prolactin and FSH disturbance