BOTULINUM TOXIN A (BTX-A) FOR TREATMENT OF PALMAR HYPERHIDROSIS

Background-Palmar hyperhidrosis is a fairly common disease with an unknown etiology. Some treatment modalities have shown benefits, the most recent of which is the injection of botulinum toxin A (BTX-A). We tried to test the beneficial effects of BTX (Dysport) in Iranian patients. Methods-Fifteen volunteers with severe palmar hyperhidrosis, diagnosed by iodine starch test, were enrolled in the study. Employing a standardized scheme, Dysport was injected intradermally into the palmar aspect of patients’ dominant hands. The distal parts of the non-dominant hands were injected by normal saline as control. Follow-up was performed using iodine starch test. Wilcoxon signed rank test was used for comparison between the cases and controls. Results-Satisfactory response to treatment was achieved in 13 out of 15 patients. Comparing the cases with the controls, Dysport showed a significant beneficial effect (p<0.001). Weakness of handgrip was seen in 13 patients. Conclusion-We suggest using Dysport in the treatment of selected cases of severe palmar hyperhidrosis.