ANTICONVULSANT EFFECT OF SOUR ORANGE FLOWERS EXTRACT IN EXPERIMENTAL PENTYLENETETRAZOL-INDUCED SEIZURES IN RAT

Seizures are disorders characterized by excessive or over-synchronized discharge of cerebral neurons and epilepsy is a group of disorders characterized by recurrent seizures. The first pharmacologically active agent against epilepsy was used in the middle of the 19th century, but we still do not have an ideal antiepileptic drug with no side effects. Sour orange (Citrus aurantium L) is one of the medicinal plants which has been grown all over the world because of its therapeutic effects and as a source of nourishment. As a traditional drug in Islamic medicine and as a folk remedy, the flowers of this plant has been used to cure seizures, heart ailment, and nervous disorders such as hysteria and neural weakness.