Synthesis and Kinetic Resolution of Furyl Substituted Secondary Carbinols by Porcine Pancreatic Lipase under Solvent Free Conditions

Chiral furyl substituted carbinols were prepared from the related carbonyl compounds and their enzymatic kinetic resolution was studied by using porcine pancreatic lipase (PPL) in transesterification reaction under solvent free condition. This study revealed that carbinols having one less bulky group on the chiral center are good substrates for PPL and the resolution proceeds with higher ee,s and less reaction time