Tetrabutylammonium Bromide Promoted Efficient and Chemoselective Trimethylsilylation of Primary and Secondary Alcohols Under Mild Reaction Conditions

A mild and efficient method for trimethylsilylation of alcohols with hexamethyldisilazane (HMDS) catalyzed by tetrabutylammonium bromide is reported. The method is highly chemoselective for the o-protection of primary and secondary alcohols in the presence of amines, thiols and tertiary alcohols