NaIO4-Catalyzed One-Pot Synthesis of Dihydropyrimidinones at Room Temperature under Solvent-Free Conditions

Sodium periodate efficiently catalyzed the three-component Biginelli reaction of an aldehyde, α β-keto ester or β-keto ketone,and urea or thiourea at room temperature under solvent-free conditions and afforded the corresponding 3,4-dihydropyrimidine-2-(1H)-ones in excellent yields