Potassium peroxydisulfate as an Efficient Oxidizing Agent for Conversion of Ethyl 3,4-Dihydropyrimidin-2(1H)-one-5-carboxylates to their Corresponding Ethyl Pyrimidin-2(1H)-one-5-carboxylates

Various ethyl 3,4-dihydropyrimidin-2(1H)-one-5-carboxylates were oxidized to their corresponding ethyl pyrimidin-2(1H)-one-5-carboxylates by potassium peroxydisulfate in refluxing aqueous acetonitrile. The products were obtained in good toexcellent yields. The effect of the nature of 4-substituent and also the nature of solvent play an important role on the rate ofoxidation.