PORCINE RESPIRATORY DISEASE COMPLEX (PRDC) - A META-ANALYSIS AND SYSTEMATIC REVIEw OF THE EFFICACY OF ENROFLOXACIN

Porcine respiratory disease complex (PRDC) is an economically significant disorder characterised by slow growth, decreased feed efficiency, lethargy, anorexia, fever, cough and dyspnea. A meta-analysis is a method of surveying and combining results of several independent clinical trials. Systematic reviews are concise summaries of the best available evidence that address sharply defined questions; they seek to assemble and examine all the high quality evidence on any given subject. This includes a comprehensive search of all potentially relevant articles and the use of explicit, reproducible criteria in the selection of articles for review. Enrofloxacin is a fluoroquinolone chemotherapeutic that was developed exclusively for use in veterinary medicine. The overall result of meta-analysis indicates a high efficacy of enrofloxacin (P < 0.001) in treating PRDC. The mortality rate was lower in the groups which used enrofloxacin (P = 0.037). Low resistance of all bacteria that cause respiratory tract infections was characterized from 0 to 7,6 %. The high efficacy of enrofloxacin in PRDC and its beneficial economic effect has been confirmed by meta-analysis and systematic review.