Protective Effect of Celery Oil, Vitamin E and Their Combination Against Testicular Toxicity in Male Rats

The protective effect of celeiy oil, vitamin E and their combination against testicular toxicity induced by sodium valporate (SVP) in male rats was studied. The experiment was carried out on 49 mature male rats distributed into 7 equal groups. The 1st group was kept as a normal control, while rats of the 2nd group were given orally SVP in a dose of 500 mg/kg /day in the last week of experiment period. The other protected groups were pretreated by oral administration of celery oil (100 and 200 mg/kg/day) and vitamin E (200 mg/kg/day), alone and in combination, respectively, for 4 weeks and received SVP as in the 2ndgroup. The pretreatment by celery oil, vitamin E and their combination in rats with testicular toxicity increased the weight of testes and accessory genital glands; sperm motility, count and viability; serum testosterone level; and alleviated the degenerative changes seen in the testes of rats with testicular injury. Conclusively, pretreatment by celeiy oil, vitamin E and their combination produces a protective effect against reproductive toxicity-induced by SVP in male rats. This study recommends that intake of celeiy oil with vitamin E may be beneficial for male patients who suffer from sexual impotency.