Effect of Zingiber officinale Roots and Cinnamon zeylanicum Bark on Fertility of Male Diabetic Rats

The effects of Zingiber officinale (ZO) roots and Cinnamon zeylanicum (CZ) bark extracts on fertility of male diabetic rats and blood glucose, insulin and testosterone levels were studied. The experiment was carried out on sixty male rats allocated into 6 equal groups of 10 animals each. One group was kept as a normal control, while rats of the other groups were given alloxan (120 mg.kg*1 / day for 3 days) by intraperitoneal injection for induction of diabetes. Group (2) was left as a diabetic control, while rats of groups (3) and (4) were given ZO extract at 250 and 500 mg.kg*1 b.wt., respectively, for 65 consecutive days to cover the period of spermatogenesis in the rat. Rats of groups (5) and (6) were given orally CZ extract at the same doses and for the same period. Results showed that oral administration of ZO and CZ extracts to diabetic rats for 65 days increased the weight of testes and seminal vesicles; improved semen quantity and quality; decreased blood glucose level, but increased serum insulin and testosterone levels. The large dose of both extracts ameliorated the degenerative lesions which seen in the testes of diabetic rats, This study recommend that intake of ZO roots and CZ bark as a drink may be beneficial for diabetic patients who suffer from sexual impotency as it improve fertility and lower the high blood glucose level in male diabetic rats.