Lethargy Following use of ProMeris Duo in Dogs - Myths and Facts

ProMeris® Duo (or ProMeris for dogs) is a novel topical ectoparasiticide contain¬ing metaflumizone and amitraz to treat and prevent infestations of fleas and ticks and to treat lice and demodectic mange on dogs. The Internet is a valuable tool for accessing and disseminating information; however, this electronic medium has also become a means for the rapid spread and expansion of rumors which may or may not be based on accurate scientific information. Following the launch of ProMeris Duo, there was a low incidence of reports of transient sedation and lethargy from clients who used ProMeris Duo on their dogs. To evaluate and address this potential concern and other theories propagated by individuals through the Internet, Fort Dodge Animal Health (FDAH) conducted a series of post-registration stud¬ies. These studies included blood level and clinical evaluations on dogs in the laboratory and home settings. Conclusions based on the results of these studies are: 1) Lethargy and sedation are rare when ProMeris Duo is applied according to the label; most cases of lethargy are due to accidental oral ingestion of the product when the product is applied incorrectly, and not due to dermal absorp¬tion, 2) Application of ProMeris Duo to dogs that also had amitraz impregnated collars did not lead to adverse events, 3) ProMeris Duo did not induce adverse events in dogs under treatment with a behavior modifying drug (i.e., fluoxetine HCL), and 4) Administration of the highly selective alpha-2 agonist dex- medetomidine to dogs treated with ProMeris Duo did not produce adverse side effects. These studies demonstrate that it is best to review product labels and results from well- controlled scientific studies when using new products rather than believe information posted on the Internet.