Efficacy of a Butafosfan and Vitamin B12 Combination (Catosal®) on Biochemical and Hematological Blood Parameters in Dogs Treated with Dexa-methasone

The effects of a simultaneous application of butafosfan plus vitamin B12 combination (Catosal®) on hepatic, pancreatic, and hematological parameters were evaluated in dogs injected subcutaneously with dexamethasone once daily for 7 days at a decreasing dose rate. Six dogs in group 1 were treated with dexamethasone and Catosal® and 6 dogs in group 2 with dexamethasone and NaCl 0.9%. GGT exceeded the upper reference limit in group 2 on study days 7, 9, and 11, whereas it remained inside the reference limits in group 1. An increase of RBC, HTC, and HB with respect to baseline values was observed in group 1 compared to group 2. A dexamethasone dependent decrease in amylase recovered faster in group 1 than group 2.