Synthesis, Characterization and Antimicrobial Activity of Long-Chain Hydrazones

Fatty acids containing hetero atoms are regarded as potential antimicrobial agents. Thus eight different hydrazones 2a–d and 3a–d were synthesized from four fatty acid hydrazides namely undecanoic hydrazide (1a), octadecanoic hydrazide (1b), 12-hydroxyoctadecanoic hydrazide (1c) and 9-hydroxyoctadecanoic hydrazide (1d) by condensing them with carbonyl group of methyl acetoacetate and acetylacetone. The structural elucidation of these compounds is based on their spectral data (IR, 1H NMR, 13C NMR and MS). These compounds were also screened for their microbial activity against Escherichia coli, Staphylococcus aureus and Staphylococcus albus by cup-plate method at 100 μg/ml of DMF using chloromycetin as a standard drug.