Design and Synthesis of Novel UDP-Mur-NAc, UDP-Mur-NAc-L-Ala and UDP-Mur-NAc-L-Ala-D-Glu mimetics

A series of novel phenylsulfonylcarbamates were designed and synthesized as mimetics of UDP-Mur-NAc, UDP-Mur- NAc-L-Ala and UDP-Mur-NAc-L-Ala-D-Glu with the potential to inhibit ATP-dependent amide-forming ligases Mur- B, C, D and E, involved in the biosynthesis of bacterial cell wall. A detailed synthesis of these compounds is presented.