Title of article
Design and Synthesis of Novel UDP-Mur-NAc, UDP-Mur-NAc-L-Ala and UDP-Mur-NAc-L-Ala-D-Glu mimetics
Author/Authors
Rok Frlan، نويسنده , , Franc Perdih، نويسنده , , Nina Cirkvencic، نويسنده , , Slavko Pecar، نويسنده , , Ales Obreza، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
11
From page
580
To page
590
Abstract
A series of novel phenylsulfonylcarbamates were designed and synthesized as mimetics of UDP-Mur-NAc, UDP-Mur- NAc-L-Ala and UDP-Mur-NAc-L-Ala-D-Glu with the potential to inhibit ATP-dependent amide-forming ligases Mur- B, C, D and E, involved in the biosynthesis of bacterial cell wall. A detailed synthesis of these compounds is presented.
Keywords
MurB , MurC , MurD , MurE , Antibacterial , inhibitors
Journal title
Acta Chimica Slovenica
Serial Year
2009
Journal title
Acta Chimica Slovenica
Record number
672137
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