Synthesis and Evaluation of Novel Bis[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles as Potent Antimicrobial Agents

A series of novel bis[4-methoxy-3-(6-aryl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol)phenyl]methanes 5a–l has been synthesized and characterized via IR, 1H NMR, 13C NMR, MS and elemental analyses. All the newly synthesized compounds were screened for their antibacterial activity against Bacillus subtilis, Bacillus sphaericu, Staphylococcus aureus, Pseudomonas aeruginosa, Klobsinella aerogenes and Chromobacterium violaceum and antifungal activity against Candida albicans, Aspergillus fumigatus, Trichophyton rubrum and Trichophyton mentagrophytes. Compounds 5e, 5f, 5h, 5i, 5k and 5l exhibited potent activity against the test bacteria and fungi, and emerged as potential molecules for further development.