Title of article
Tau phosphorylation and assembly
Author/Authors
Alberto Gomez-Ramos، نويسنده , , Mark A. Smith، نويسنده , , George Perry، نويسنده , , Jesus Avila، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
7
From page
33
To page
39
Abstract
Neurofibrillary tangles, one of the aberrant structures found in the brain of Alzheimerʹs disease patients are mainly composed of tau in hyperphosphorylated form.Thus, a possible relation between phosphorylation and assembly of tau proteins has been analysed. By doing in vitro studies we have observed that in certain conditions, where compounds from oxidative stress are present, the capacity of tau for self assembly increases upon phosphorylation.
Keywords
tau , phosphorylation , tau kinases , oxidative stress
Journal title
Acta Neurobiologiae Experimentalis
Serial Year
2004
Journal title
Acta Neurobiologiae Experimentalis
Record number
672666
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