Chemopreventive and Therapeutic Role of Nutraceuticals in Mice Loaded with Solid Tumo

The present study focused on evaluating the effect of different nutraceutical combinations including primarose, omega 3 fatty acids, silymarin, coenzyme Q10, antioxidants on tumor growth as well as the metabolic impact-induced by Ehrlich ascites carcinoma (EAC) inoculation in female mice. After 60 days of oral administration of the selected nutraceutical combinations, the tumor size was recorded. Also, serum and liver samples were obtained for different biochemical analyses. These analyses included the determination of serum arginase, L-fucosidase, lipid peroxidation, nitric oxide levels and total antioxidant capacity. Moreover, hepatic Na+- K+/ATPase activity, sodium and potassium content of hepatic tissue were also assayed. The present results revealed that EAC inoculation (0.2ml of EAC which contains 2.5*106 cells) causes significant increase in serum arginase, L-fucosidase, , lipid peroxidation, nitric oxide levels and hepatic potassium concentrations, while, total antioxidant capacity, hepatic Na+/K+-ATPase activity and sodium concentrations were significantly decreased in EAC inoculated mice when compared to control one. On the other hand, the selected nutraceutical combinations significantly reduced tumor size and markedly improved most of the biochemical parameters associated with the inoculation of EAC. This study highlighted the potential effectiveness of the selected nutraceutical combinations in ameliorating the growth of implanted EAC as well as modulating the biochemical parameters that are involved during tumor development in mice