Hindiii Polymorphism of Lipoprotein Lipase Gene and its Contribution to Coronary Artery Disease in Egyptians

Coronary artery disease (CAD) is one of the main leading causes of death worldwide. The aim of this study is the detection of the HindIII polymorphism in patients with coronary artery disease (CAD) to determine the importance of this mutation as a risk factor. The study included forty CAD patients and twenty healthy subjects. They were genotyped for HindIII LPL using polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) technique, and the findings were analyzed for association with CAD and with plasma levels of lipid parameters; total cholesterol (T-chol), low density lipoprotein- cholesterol (LDL- C), high density lipoprotein - cholesterol (HDL-C) and triglycerides (TG). Patients with HindIII +ve allele were at higher risk of developing CAD than those with -ve allele (oddʹs ratio: 2.8 & 95% CI 0.89-8.92). Significant predictors of CAD were HDL-C followed by serum level of TG then LDL-C. In conclusion HindIII polymorphism in LPL gene was associated with CAD severity, due to its significant implication on lipid metabolism. Further studies are required, in particular looking at the influence on clinical outcome