Title of article :
THE EFFECT OF SELEGILINE AND BROMOCRIPTINE IN THE PROPHYLAXIS OF PERPHENAZINE-INDUCED PSEUDOPARKINSONISM IN RAT: A COMPARATIVE STUDY
Author/Authors :
Arzi، A نويسنده Department of Pharmacology & Toxicology, School of Pharmacy, Ahwaz Jundishapur University of Medical Sciences Arzi, A , Hemmati ، AA نويسنده Department of Pharmacology and Toxicology, School of Pharmacy Hemmati , AA , Pipelzadeh، MH نويسنده School of Medicine, Ahwaz Jundishapur University of Medical Sciences Pipelzadeh, MH , Latifi ، SM نويسنده School of Health Ahwaz Jundishapur University of Medical Sciences Latifi , SM , Ramesh، F نويسنده Department of Pharmacology & Toxicology, School of Pharmacy, Ahwaz Jundishapur University of Medical Sciences Ramesh, F
Issue Information :
فصلنامه با شماره پیاپی 1 سال 2006
Abstract :
Parkinsonism is a neurodegenerative disease that is defiend by certain symtom as muscle rigidity , impaired movement , tremor and disorientation of body. The aim of the present study was to compare the efficacy of selegiline and bromocriptine in the prevention of experimentally induced pseudoparkinsonism in rat. Perphenazine (5mg/kg) was used (IP) as the inducing agent. Different groups of rats were pretreated by either selegiline (2.5, 5, 10, and 20mg/kg), or effective dose of bromocriptine (30mg/kg). The degree of prevention of catatonic reaction was compared with control group. The results showed all selegiline-treated groups had significant reduction in the catatonic reaction relative to sham treated group. In addition, 20mg/kg selegiline had more intensive effect to reduce the catatonic reaction than bromocriptine (30mg/kg). Selegiline seems to be a suitable drug to prevent perphenazine–induced catatonia in rat.
Journal title :
Jundishapur Journal of Natural Pharmaceutical Products (JJNPP)
Journal title :
Jundishapur Journal of Natural Pharmaceutical Products (JJNPP)
