Modulating role of Panax ginseng in phase - II reaction of hepato - biotransformation in Albino rats following mercuric chloride intoxication

ABSTRACT Background: The fate of xenobiotics that is present, increasing day by day. The increasing fates altered or inhibit the metabolic activities like detoxification and biotransformation. Methods: The present study highlights this slow biotransformation and detoxification on the basis of specific enzymes which have a say in assessment of mercuric chloride toxicity and modulation by Panax ginseng root extract. Results: The results revealed that mercuric chloride caused significant increase in liver weight, glutathione - s - transferase (GST), glutathione peroxidase (GPX), glutathione reductase (GR) and significant decrease in glutathione (GSH) level, while Panax ginseng alone and combination with mercuric chloride caused significant decrease in liver weight, glutathione - s - transferase (GST), glutathione peroxidase (GPX), glutathione reductase (GR) and glutathione (GSH) level. Conclusion: The results suggest a modulating role of this root powder extract against raised enzyme levels and liver weight induced by mercuric chloride in albino rat.