Lack of Polymorphism in Human Interleukin-2 Gene among Malarial Patients from District Bannu, Pakistan

Inflammatory cytokines play an important role in human immune responses to malarial disease. However, role of these mediators in disease pathogenesis and the relationship between host and injury remain unclear. This study was aimed at finding out polymorphism in human Interleukin-2 gene among malarial patients. Blood samples were collected from 122 patients suffering from malaria from Malaria Control Program operating in women and children District Head Quarter, Hospital at Bannu, Pakistan during summer 2007. Isolated human DNA was amplified by PCR using 3 exons of human IL-2 gene. All PCR products were of the same size as that of exon deduced from gene bank thus showing lack of polymorphism in Human Interleukin-2 gene. It was concluded that there are some invariant allele copies prevalently associated as a result of static and reduced genetic drift among population of District Bannu, Pakistan. © 2010 Friends Science Publishers