Title of article :
Chemical composition, antimicrobial activity and antiviral activity of essential oil of Carum copticum from Iran
Author/Authors :
Kazemi Oskuee، Reza نويسنده , , Behravan، Javad نويسنده , , Ramezani، Mohammad نويسنده ,
Issue Information :
فصلنامه با شماره پیاپی 0 سال 2011
Pages :
8
From page :
83
To page :
90
Abstract :
Objectives: Evaluation of therapeutic effects of Carum copticum (C. copticum) has been the subject of several studies in recent years. Thymol the major component of C. copticum is a widely known anti-microbial agent. In this study, the antibacterial and anti viral activities of essential oil of C. copticum fruit were determined. Materials and Methods: Essential oil of C. copticum was analyzed by means of gas chromatography-mass spectrometry (GC-MS). The antimicrobial activity of the oil was evaluated against six Gram (+/-) bacteria and fungi, using the micro broth dilution technique. Antiviral activity of the essential oil was evaluated using a Bacillus phage CP51. Results: From the ten identified constituents, representing 98.7% of the oil, thymol (72.3%), terpinolene (13.12%) and o-cymene (11.97%) were the major components. It was found that the oil exhibited strong antimicrobial activity against Staphylococcus aureus (S. aureus) and Bacillus subtilis (B. subtilis) (MIC, 0.00025% v/v). Furthermore, the antiviral activity of the oil was evaluated by plaque reduction assay. Conclusion: The essential oil showed an antiviral activity against phage when phage was pre-incubated with the essential oil prior to its exposure to B. cereus and without any pre-incubation with the phage, suggesting that the oil directly inactivated virus particles.
Journal title :
Avicenna Journal of Phytomedicine AJP)
Serial Year :
2011
Journal title :
Avicenna Journal of Phytomedicine AJP)
Record number :
679114
Link To Document :
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