Author/Authors :
Ostadrahimi، Alireza نويسنده Nutrition Research Center, Department of Nutrition, Faculty of Health and Nutrition, Tabriz University of Medical Sciences , , Ghaffari، Aida نويسنده Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences , , Somi، Mohammad-Hossein نويسنده , , Safaiyan، Abdolrasoul نويسنده Department of Statistics and Epidemiology, Faculty of Health and Nutrition, Tabriz University of Medical Sciences , , Modaresi، Jabiz نويسنده Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences ,
Abstract :
ABSTRACT
Background: Gastric cancer is the fourth most common malignancy in the world. Honey is a
complex mixture of special biological active constituents. Honey possesses antioxidant and antitumor
properties. Nutritional studies have indicated that consumption of honey modulates the
risk of developing gastric cancer. On the other hand, apoptosis has been reported to play a decisive
role in precancerous changes. Our chief study was conducted to assess the relationship between
consumption of honey and apoptosis in human gastric mucosa.
Method: This cross-sectional study was conducted on 98 subjects over 18 years old, referred to
two hospitals in Tabriz, Iran. Subjects were undergone an upper gastrointestinal endoscopy, 62
subjects were finally enrolled. Honey consumption was assessed by a Food Frequency Questionnaire
(FFQ) and apoptosis was detected by TUNEL technique. We tested polynomial curve to
find the best fit between honey consumption and apoptosis.
Results: A positive relation between honey consumption and apoptosis was found (P=0.024).
Our results indicated that the final and the best fit curve was: apoptosis = 1.714+1.648(honey
amount) - 0.533(honey amount)2 +1.833×10-5(honey amount)7.
Conclusion: Honey consumption had positive effects on gastric cancer by inducing apoptosis in
gastric mucosa.
