DISTRIBUTION MODEL OF SERUM LIPOPROTEIN (A) CONCENTRATION IN A HEALTHY IRANIAN POPULATION LIVING IN KHUZESTAN PROVINCE, IRAN. 2004.

Based on many epidemiologic studies, lipoprotein (a) [Lp(a)] with its peculiar structural properties was proposed as independent, risk factor for cardiovascular and thrombotic cerebral events. Since, genetic effect plays a paramount role in determining the final serum concentration, the reference serum concentration for this particle exhibits a wide variation among different population and even within a family. In order to prevent its pathologic effect which has been related to its high serum concentration it is a prerequisite to determine its serum concentration distribution model in a particular population before any therapeutic measure is arranged. To accomplish this goal a group of 350 healthy volunteers living in southern province of Khuzestan, Iran, were analyzed for their Lp (a) serum concentration employing and isoform- insensitive ELISA technique. The obtained result showed skewed distribution toward lower concentration ranging from 3 to 53 mg/dL with mean, median and standard deviation as 14.42, 12.0 and 8.46 mg/dL.