Author/Authors :
Mousavi، Seyed Ghafur نويسنده , , Ghasemi، Mohsen نويسنده , , Maracy، Mohammad Reza نويسنده , , Ebrahimi ، Amrollah نويسنده Behavioral Sciences Research Center, Department of Psychiatry, School of Medicine, Isfahan University of Medical Sciences (IUMS), Isfahan , , Barekatain، Majid نويسنده , , Noori، Fariba نويسنده Behavioral Sciences Research Center, Department of Psychiatry, School of Medicine, Isfahan University of Medical Sciences (IUMS), Isfahan ,
Abstract :
Background: Electroconvulsive therapy (ECT) is one of the most
efficacious treatment for major depressive disorder (MDD), it is
also used as a rapid and efficacious treatment for other psychiatric
disorders, especially treatment resistant ones. The cognitive
impairment is one of the most important side effects of ECT.
This study examined the Memoral herbal efficacy in prevention of
ECT?induced memory impairment.
Methods: In a randomized clinical trial, 70 patients with mood
disorders who were candidates for ECT enrolled in either Memoral
or Control group, and received either Memoral or placebo. The
memory was assessed by Addenbrook Cognitive Examination
(ACE), and the findings were analyzed by ANOVA under SPSS18.
Results: The Memoral group patients showed significantly higher
total ACE scores than placebo group (P < 0.001). The scores of
attention and orientation, verbal fluency and memory subscales
not only never decreased during the study in Memoral group,
but also increased. There was no significant difference between
these scores of Memoral and placebo groups for the subscales of
language and visuospacial ability.
Conclusion: The Memoral herbal is an efficacious and safe choice
in prevention of ECT? induced cognitive impairment.
