Author/Authors :
Hashemipour، Mahin نويسنده , , Salehi Abari، Shima نويسنده Department of Pediatrics, Faculty of Medicine, and Child Health Promotion Research Center, IUMS, Isfahan , , Mostofizadeh، Neda نويسنده Department of Pediatrics, Faculty of Medicine, and Child Health Promotion Research Center, IUMS, Isfahan , , Haghjooy Javanmard، Shaghayegh نويسنده Physiology Research Center , , Esmail، Nafiseh نويسنده Immunology Department, Faculty of Medicine and Applied Physiology Research Center, IUMS, Isfahan , , Hovsepian، Silva نويسنده Department of Pediatrics, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan , , AMINI، MASOUD نويسنده , , Kelishadi، Roya نويسنده , , Hasanzadeh، Akbar نويسنده Department of Biostatistics and Epidemiology, School of Health, IUMS, Isfahan, Iran , , Mirouliaei، Mehrdad نويسنده Department of Pediatric Endocrinology, Yazd University of Medical Sciences, Yazd ,
Abstract :
Background: Considering the role of maternal thyroid stimulating
hormone (TSH) receptor blocking antibody (TRAb) in the etiology of
congenital hypothyroidism (CH), this study aimed to determine TRAb
among patients with CH in Isfahan, Iran.
Methods: In this case–control study, patients with CH and their mothers
were compared with a group of healthy neonates and their mothers.
Venous blood samples were obtained for measurement of TRAb using
enzyme-linked immunosorbent assay (ELISA) method among mothers
and their neonates. TSH of mothers was also determined.
Results: The case group consisted of 65 patients with CH and their
mothers; controls were 148 healthy neonates and their mothers. The
prevalence of positive TRAb in patients with CH and their mothers
was higher than in the control group (81.5% vs. 1.3% in mothers and
80% vs. 0% in neonates, respectively, P < 0.05). The relationship between
the TRAb and occurrence of CH was significant (P < 0.05), whereas the
corresponding figure was not significant for TRAb and the level of
maternal and neonatal TSH in case and control groups (P > 0.05).
Conclusion: It seems that autoimmunity has an important role in
the etiology of CH. Further studies are necessary to determine other
autoantibodies in CH patients.
