Author/Authors :
Sadeghirad، Behnam نويسنده , , Haghdoost، Ali-Akbar نويسنده MD, PhD of Epidemiology and Biostatistics, Department of Epidemiology and Biostatistics, School of Health, KUMS, Kerman , , Amin-Esmaeili، Masoumeh نويسنده MD, MPH, Iranian Research Center for HIV/AIDS (IRCHA), Tehran University of Medical Sciences (TUMS), Tehran , , Shahsavand Ananloo، Esmaeil نويسنده MD, Psychiatric Research Center, Roozbeh Psychiatric Hospital, TUMS, Tehran , , Ghaeli، Padideh نويسنده PharmD, Psychiatric Research Center, Roozbeh Psychiatric Hospital, TUMS, Tehran , , Rahimi-Movaghar، Afarin نويسنده MD, MPH, Iranian Research Center for HIV/AIDS (IRCHA), Tehran University of Medical Sciences (TUMS), Tehran , , Talebian، Elham نويسنده MD, Medical Students Research Center, KUMS, Kerman , , Pourkhandani، Ali نويسنده MD, Medical Students Research Center, KUMS, Kerman , , Noorbala، Ahmad-Ali نويسنده , , Barooti، Esmat نويسنده MD, Women Health Affairs Office, Ministry of Health and Medical Education, Tehran ,
Abstract :
Objectives: There are a large number of primary researches on the
prevalence of major depressive disorder (MDD) in Iran; however,
their findings are varied considerably. A systematic review was
performed in order to summarize the findings.
Methods: Electronic and manual searches in international and
Iranian journals were conducted to find relevant studies reporting
MDD prevalence. To maximize the sensitivity of the search, the
references of relevant papers were also explored. We explored the
potential sources of heterogeneity such as diagnostic tools, gender
and other characteristics using meta-regression model. The combined
mean prevalence rates were calculated for genders, studies
using each type of instruments and for each province using metaanalysis
method.
Results: From 44 articles included in the systematic review, 24
reported current prevalence and 20 reported lifetime prevalence of
MDD. The overall estimation of current prevalence of MDD was
4.1% (95% CI: 3.1-5.1). Women were 1.95 (95% CI: 1.55-2.45)
times more likely to have MDD. The current prevalence of MDD
in urban inhabitants was not significantly different from rural
inhabitants. The analysis identified the variations in diagnostic
tools as an important source of heterogeneity.
Conclusions: Although there is not adequate information on
MDD prevalence in some areas of Iran, the overall current prevalence
of MDD in the country is high and females are at the greater
risk of disease.
