Author/Authors :
Esmaili-Hesari، Ramezan-Ali نويسنده Department of Epidemiology, School of Public Health, Tehran University of Medical Sciences, Tehran , , Homai-Shandiz، Fatemeh نويسنده Department of Radiotherapy, Cancer Research Centre, Mashad University of Medical Sciences, Mashad , , Motevallian، Abbas نويسنده Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran , , Madjd، Zahra نويسنده Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran , , Solaymani-Dodaran، Masoud نويسنده Dept. of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran , , Asadi-Lari، Mohsen نويسنده Oncopathology Research Centre, Tehran University of Medical Sciences, Tehran, Iran ,
Abstract :
Background: Oesophagogastric (OG) cancer as a globally common
and deadly malignancy, which is widely spread in Northeast Iran, has an
extensive impact on health-related quality of life (HRQL). Demographic
and histopathologic changes have been apparent in oesophagogastric
cancer, therefore. HRQL could be used, as an outcome, to assess
and determine the efficacy and impact of cancer care.
Methods: A consecutive sample of upper-gastrointestinal cancer
patients admitted to the main oncology/ radiotherapy departments in
the North-East of Iran were recruited into the study. All participants
completed the European Organisation for Research and Treatment of
Cancer (EORTC) QLQ-C30 and QLQ-OG25questionnaires in a face
to face interview.
Results: Of the total 275 patients participated in the study, 54%
had oesophageal, 34% stomach and 12% OG junction cancers.
About 73.1% had TNM (tumour, node, metastasis) staging; of
which 69% were in stage III and IV. The most common type of
cancer in oesophagus was SCC (95.3%) in lower third, ADC in
stomach (97.8%) and in the OG junction (93.8%). Patients with
stomach or OG junction tended more to present in higher stages
(P < 0.001). Unlike QLQ-C30, the EORTC QLQ-OG25 was able to
differ patients significantly in anxiety scale (P = 0.01), body image,
chocking and weight loss (P < 0.05). Those who had self care ability
had better quality of life scores (P < 0.001) in more scales and items.
Conclusion: SCC is predominant type of upper GI cancer in
Khorasan provinces similar to the high risk area in Northern Iran.
The specific health-related quality of life tool (EORTC QLQOG25)
was able to distinguish most of the symptoms in patients
with upper GI cancer.
