Evaluation of Compatibility of Lamivudine with Tablet excipients and a novel synthesized polymer

This study reports compatibility of antiviral drug lamivudine with various selected excipients and a novel synthesized polymer, for the development of its controlled release formulation. Differerntial scanning calorimetry (DSC), Isothermal stress testing (IST) and Fourier transform infra-red (FT-IR) spectral analysis was performed to access the compatibility. The compatibility study was performed with various common excipients like spray dried lactose, poly vinyl pyrrolidine K-30, magnesium stearate, talc and a novel synthesized polymer cross-linked moth bean starch with lamivudine. The results confirmed that the tablet excipients were compatible with anti HIV drug lamivudine.