Title of article :
Preparation of methyl (1R,2S,5S)- and (1S,2R,5R)-2-amino-5-tert-butyl-cyclopentane-1-carboxylates by parallel kinetic resolution of methyl (RS)-5-tert-butyl-cyclopentene-1-carboxylate
Author/Authors :
Davies، Stephen G. نويسنده , , Long، Marcus J. C. نويسنده , , Smith، Andrew D. نويسنده , , Dez، David نويسنده , , Hammouni، Mohamed M. El نويسنده , , Garner، A. Christopher نويسنده , , Garrido، Narciso M. نويسنده , , Morrison، Rachel M. نويسنده , , Sweet، Miles J. نويسنده , , Withey، Jonathan M. نويسنده ,
Abstract :
Comparison of the kinetic and parallel kinetic resolutions of methyl (RS)-5-tert-butylcyclopentene-1-carboxylate allows for the efficient synthesis of both (1R,2S,5S)- and (1S,2R,5R)-enantiomers of methyl 2-amino-5-tert-butyl-cyclopentane-1-carboxylate.
