Author/Authors :
Shams Shahemabadi، A نويسنده Immunology department, Faculty of medicine, Shahid Sadoughi University of Medical Sciences and Health Services. , , Salehi، F نويسنده Central laboratory of Yazd, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran , , Hashemi، A نويسنده Hematology, Oncology and Genetics Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran , , Vakili، M نويسنده Community Medicine Department, Faculty of Medcine, Shahid Sadoughi University of Medical Sciences and Health Services , Yazd ,Iran. , , Zare، F نويسنده Immunology department, Faculty of medicine, Shahid Sadoughi University of Medical Sciences and Health Services. , , Esphandyari، N نويسنده Saman Complex, Yazd,Iran. , , Kashanian، S نويسنده Immunology department, Faculty of medicine, Shahid Sadoughi University of Medical Sciences and Health Services ,
Abstract :
Abstract
Background
There is a decrease in vaccine-specific antibody to certain vaccine-preventable diseases in
children after chemotherapy, but the frequency of non-immune patients is not clear. In the
present case-control study, was taken under investigation protection level to Hepatitis B infection
in children 6 months after completing chemotherapy.
Materials and Methods
In this study 68 patients with cancer and 68 healthy children were enrolled. Patients were 1.5 -
12 years old with completed standard chemotherapy at least for 6 months. All the patients and
healthy children were negative for HBsAg and HBeAg and had received Hepatitis B vaccination.
IgG antibody concentrations against Hepatitis B Virus (HBV) were determined in the patients
receiving chemotrapy and healthy subjects serum by ELISA method. IgG antibody titer > 10
mIU/ml was considered as baseline protective titer for preventing HBV infection.
Results
Anti-HBs antibody titer in 19.12% of patients was less than 10 mIU/ml and 11.76% of the
patients had borderline antibody titer (10-20 mIU/ml). In healthy subjects, 2.94% and 5.88% had
antibody titer < 10 mIU/ml and 10-20 mIU/ml, respectively. According to statistical analysis,
frequency of non immune subjects in children with cancer was significantly higher than those in
healthy children (P-value=0.024).
Conclusion
HBV vaccination post-intensive chemotherapy in the children with cancer is strongly
recommended.
