Influence of Clonidine on the Chemodynamic Stability and Stress Response in the Course of Surgery on General Anesthesia

This work provides results of therapeutic efficacy testing and clonidine toleration in moderating of perioperative tachicardia and hypertension, as well as reducing the needs for anaestathic drugs, thus providing better patientsʹ cardiovascular stability. Material and methods: The study involved 60 patients, that were subdued to elective non-cardiosurgical operations in general anaesthesia. One half of the patients was administred the Clonidine, 0,2|ig/kg/min in solution, while the other half served as a control group. Results: of the study it was evident that the Clonidine group had considerably less stress response, which was shown through variaton of cortisol levels during operation, glicemy levels and vital parameters. There was a statisticly significant difference (p<0,001) in cortisol serum levels and glicemy beetwen these two groups. Complications during anesthesia were fewer in the Clonidine group, and the consumption of anesthetic drugs was also lower. Conclusion: Clonidine effects were favourable during anaesthesia.