Analysis of Inflammatory Parameters in Diabetes Mellitus Type 2 Patients with or Without Metabolic Syndrome

The goal of this study was to determine the association between serum inflammatory parameters and diagnosed diabetes mellitus type 2. Patients and methods: The study included 100 patients of both genders from 49 to 83 years old. Based on ATP III criteria, patients were divided into two groups: A) DM2, MS - diabetic patients with metabolic syndrome and group B) DM2, NMS - diabetic patients without metabolic syndrome. The results showed statistically significant and accelerated sedimentation in group A (41.85 ± 4.99mm) than in group B (26.4 ± 3.1mm) with statistical difference p<0.05. Average concentrations of plasma fibrinogen in patients of group A was higher (14.53 ± 0.65) compared to the concentration of fibrinogen in plasma of patients in group B (11.21 ± 0.50). The difference was statistically significant (p<0.001). The average concentration of alpha 1 globulin in the plasma of patients of group A was higher (0.053 ± 0.003) compared to the concentration of alpha 1 globulin in the plasma of patients in group B (0.042 ± 0.002). The difference was statistically significant (p<0.05). The average concentration of alpha 2 globulin in plasma of patients of group A was higher (0.12 ± 0.005) compared to the concentration of alpha 2 globulin in plasma of patients in group B (0.10 ± 0.004). The difference was statistically significant (p <0.05). The average number of leukocytes in the blood of patients of group A was higher (10.07 ± 0.52) compared to the average number of leukocytes in the blood of patients in group B (9.25 ± 0.47), but the difference was not statistically significant. Albumin-globulin ratio in blood group A patients (1.06 ± 0.03) was lower compared to the albumin-globulin ratio in blood of patients in group B (1.11 ± 0.02), but the difference was not statistically significant. Conclusion: Statistical results showed significant increase in serum fibrinogen, alpha 1 and 2 globulin, and accelerated erythrocyte sedimentation rate. Not statistically significant increase in the number of leukocytes, and decreased albumin-globulin ratio (A/G) between the two groups.