Author/Authors :
Bertelsen، S?ren نويسنده , , Halland، Nis نويسنده , , Bachmann، Stephan نويسنده , , Marigo، Mauro نويسنده , , Braunton، Alan نويسنده , , J?rgensen، Karl Anker نويسنده ,
Abstract :
The first organocatalytic enantioselective (alpha)-bromination of aldehydes and ketones is presented; a C2-symmetric diphenylpyrrolidine catalyst afforded the (alpha)-brominated aldehydes in good yields and up to 96% ee, while ketones were (alpha)-brominated by a C2-symmetric imidazolidine in up to 94% ee; furthermore, the organocatalytic enantioselective (alpha)-iodination of aldehydes is also demonstrated to proceed with up to 89% ee.
