Title of article :
Double diastereoselective [3,3]-sigmatropic aza-Claisen rearrangements
Author/Authors :
Davies، Stephen G. نويسنده , , Smith، Andrew D. نويسنده , , Garner، A. Christopher نويسنده , , Nicholson، Rebecca L. نويسنده , , Osborne، James نويسنده , , Savory، Edward D. نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
Asymmetric [3,3]-sigmatropic aza-Claisen rearrangement of the (Z)-N-allyl-N,O-silylketene aminal of (3S,4E,(alpha)R)-1-benzyloxy-3-(Npropionyl-N-(alpha)-methylbenzylamino)hex-4-ene furnishes (2S,3R,4E,(alpha)R)-N-(alpha)-methylbenzyl-2,3-dimethyl-7-benzyloxyhept-4enamide in >92% d.e.; rearrangement of the diastereomeric (3R,4E,(alpha)R)-(Z)-N,O-silylketene aminal proceeds with low diastereoselectivity.
Keywords :
Identifiability , Parametric bootstrap , Restricted latent class models , Model diagnosis , Goodness of fit
Journal title :
CHEMICAL COMMUNICATIONS - LETCHWORTH
Journal title :
CHEMICAL COMMUNICATIONS - LETCHWORTH
