Author/Authors :
لهر باير، ليويا نويسنده 3rd Dept Internal Med, Cardiology and Emergency Med, Wilhelminenspital, Vienna, Austria Leherbauer, Livia , سونك كوين، شارلوت نويسنده Institute of Nuclear Medicine with PET-Center, Wilhelminenspital, Vienna, Austria Sonneck-Koenne, Charlotte , زكوي، سيد رسول نويسنده Nuclear Medicine Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Zakavi, Seyed Rasoul , هايولا، ديانا نويسنده 3rd Dept Internal Med, Cardiology and Emergency Med, Wilhelminenspital, Vienna, Austria Haoula, Diana , حيدري، بامداد نويسنده 3rd Dept Internal Med, Cardiology and Emergency Med, Wilhelminenspital, Vienna, Austria Heydari, Bamdad , آگو، گادسويل نويسنده Institute of Nuclear Medicine with PET-Center, Wilhelminenspital, Vienna, Austria Agu, Godswill , نول، پيتر نويسنده Department of Nuclear Medicine and PET Center, Wilhelminenspital, Montleartstr. 37, 1171 Vienna, Austria Knoll, Peter , گويل تكين، سلما نويسنده Institute of Nuclear Medicine with PET-Center, Wilhelminenspital, Vienna, Austria Gueltekin, Selma , هوبر، كورت نويسنده 3rd Dept Internal Med, Cardiology and Emergency Med, Wilhelminenspital, Vienna, Austria Huber, Kurt , ميرزايي چوپاني، سيروس نويسنده ,
Abstract :
Introduction: The aim of this study was to evaluate the impact of measurement of coronary artery calcification
score (CAC) in patients with suspected coronary artery disease (CAD) and a normal myocardial perfusion scan.
Methods: In a prospective study we measured the calcium score of 74 patients (29 m, 45 f, mean age 58.7 (m)
and 64.4 (f)) with suspicion of CAD and a normal perfusion scan. In all patients a pharmacological stress
myocardial perfusion imaging (MPI) with dipyridamole was performed. Both the myocardial perfusion
scintigraphy and calcium scoring were performed on a T6 Symbia gamma camera (Siemens, Knoxville, USA).
Attenuation correction was performed using a low dose CT.
Results: The mean total CAC score was 182.6±435.7 and ranged from 0 -2309. 21/29 of the male patients
(72%) and 17/45 of the female patients (38%) had an Agatston score of > 10. There were 9 cases (5m, 4f) with a
calcium score of > 400 and 3 cases (2m, 1f) with a calcium score > 1000. No cardiac event was noted in these
patients during a mean follow up time of 10.3 months (range 7-13 months, median 11 months) except one
cardiac death of a patient with total Agatston score of 278. Seven patients also underwent angiography because
of their clinical symptoms, 4 of which (57%) had an elevated Agatston score.
Conclusion: Our study showed that calcium score measurement accompanied with SPECT imaging is feasible
in routine myocardial perfusion imaging with SPECT/CT machines. Calcium score measurement in patients
with normal stress myocardial perfusion scintigraphy, may be useful in risk stratification of the patients. Further
prospective studies with larger patient numbers and longer follow-up time are needed to find out the impact of
this advantage by hybrid imaging
