Optical fiber-based on-line UV/Vis spectroscopic monitoring of chemical reaction kinetics under high pressure in a capillary microreactor

With a miniaturized (3 (mu)L volume) fiber-optics based system for on-line measurement by UV/Vis spectroscopy, the reaction rate constants (at different pressures) and the activation volumes ((delta)V(not equal)) were determinined for a nucleophilic aromatic substitution and an aza Diels–Alder reaction in a capillary microreactor.