Study of publication bias in meta-analysis using trim and fill method

ABSTRACT: Meta-analysis includes statistical methods in combining the results of several studies. However, it might be affected by publication bias. Publication bias is the preferred publication of statistically significant results over insignificant ones. Therefore, if the source of meta-analysis studies are published scientific articles, they might face publication bias. Trim and fill is a method for correcting publication bias in meta-analysis. In this article we analyze thirteen studies on CISAPRIDE, related to Hartung and Knapp, 2001, and correct their estimated meta-analysis using trim and fill method.