MembranoProliferative GlomeruloNephritis in Down Syndrome

ABSTRACT: Down syndrome patients have many complications that affect their survival. A variety of nephrological abnormalities have been reported in some of them. We report a case of 38-years-old man with Down syndrome who presented with right leg pain & erythema, pitting edema and mild fever and history of cardiac valvular disease. His laboratory tests showed Creatinine rising and proteinuria. Biopsy of kidneys showed Memberano Proliferative GlomeruloNephritis (MPGN). We conclude that early diagnosis and treatment of renal disease is necessary for increasing the survival of Down syndrome patients.