Synthesis of 1,2- dihydroisoquinolines using isoquinoline and activated acetylenes with NH-acids

A straightforward and efficient method for the synthesis of 1,2-dihydroisoquinolines via the one-pot, threecomponent reaction of isoquinoline, activated acetylenes and NH- acid in water without using any catalyst is reported. The method offers several advantages including high yields of products and an easy work-up procedure.