Solvent free solid support synthesis of arylmethylene bis (3-Hydroxy-2- cyclohexene-1-ones) and Xanthenediones derivatives by microwave irradiation

An efficient and effective microwave-assistant synthesis of arylmethylene bis(3-hydroxy-2-cyclohexene-1-ones) 1 and Xanthenediones 2 by using neutral alumina, followed by conc. Sulfuric acid catalyzed dehydration reaction was developed starting from dimedone and various aromatic aldehydes. This method provides several advantages such as high yields and simple purification procedure of products by non-chromatographic method, i.e., by simple recrystallization from ethanol. In addition, this process devoid of any expensive catalyst. The short reaction time and simple reaction condition offers a scope for the synthesis of biologically and medicinally interesting molecules.