A rapid synthesis of functionalized dimethylaminothiazoles from reaction of bromoketones with thioamide derevatives of tetramethyl guanidine in an ionic liquid

An efficient and rapid synthesis of dimethylaminothiazole via the reaction of ethyl bromopyruvate or phenacyl bromides with 2-(amidosulfanylenemethyl)-1,1,3,3-tetramethylguanidines is described in an ionic liquid at room temperature. The method is simple, rapid, and practical and the products are generated in good yields.