Author/Authors :
wassel، Anwar A. نويسنده National Organization for Drug Control and Research, (NODCAR) P.O. Box 29, Cairo, Egypt , , Amin، A. S. نويسنده Department of Chemistry, Faculty of Science, Benha University, Benha, Egypt , , Dessouki، H. A. نويسنده Department of Chemistry, Faculty of Science, Benha University, Benha, Egypt , , Hendawy، A. M. نويسنده National Organization for Drug Control and Research, (NODCAR) P.O. Box 29, Cairo, Egypt ,
Abstract :
The adsorptive and electrochemical oxidation behavior of Cilostazol has been
studied at CPE and GCE in Britton - Robinson (BR) (pH 2.0 to 12.0). The anodic oxidation at
663 and 682 mV for CPE and GCE respectively. Differential pulse voltammetry was used to
determine Cilostazol in the pure and in pharmaceutical formulations. The linear calibration
was obtained from: 4.0×10-7–6.40×10-6 M and 5×10-7–8.7×10-6 M for carbon past and glassy
carbon electrode. The percentage recoveries were found in the ranges: 99.50-100.80%, 99.20
-100.10% at carbon past and glassy carbon electrodes, respectively. The RSD for five
measurements were found in the ranges: 0.403-0.742% and 0.657-0.84 %,. The method was
applied to determine Cilostazol has in dilute urine sample and dosage forms and compared
with official methods.
