Author/Authors :
Babaei، Ali Reza نويسنده , , Farshbaf، Mojtaba نويسنده Department of Chemistry, Arak University, Arak, P.O. Box 38156-8-8349, Iran , , Afrasiabi، Mohammad نويسنده Young Researchers Club, Islamic Azad University, Shoushtar Branch, Shoushtar, Iran , , Dehdashti، Aliyeh نويسنده Department of Chemistry, Arak University, Arak, P.O. Box 38156-8-8349, Iran ,
Abstract :
A chemically modified electrode is constructed based on multi-walled carbon
nanotube modified glassy carbon electrode (MWCNTs/GCE) as a sensor for simultaneous
determination of acetaminophen (ACT) and indomethacin (INDO) in phosphate buffer (pH 7)
solution. The measurements were carried out using differential pulse voltammetry (DPV),
cyclic voltammetry (CV) and chronoamperometry (CA) methods. DPV measurements
showed that the linear relationship between oxidation peak current and concentration of ACT
and INDO were in the range of 3 ?M to 400 ?M, and 10 ?M to 330 ?M, respectively. Under
optimal conditions the modified electrode exhibited high sensitivity and stability for both
ACT and INDO determination, making it a suitable sensor for the simultaneous
submicromolar detection of ACT and INDO in solutions. The analytical performance of this
sensor has been evaluated for detection of ACT and INDO in human serum, human urine and
a pharmaceutical preparation with satisfactory results.
