The levelling effect of solvational imbalances in the reactions of oximate alpha-nucleophiles with electrophilic phosphorus centers. Relevance to detoxification of organophosphorus esters

A study of the reactions of oximate alpha-nucleophiles with diisopropylphosphorofluoridate (DFP) and two model phosphonates, has revealed either a levelling-off in reactivity or a bell-shaped behaviour in accordance with a critical decoupling of desolvation and bond formation (solvational imbalances); the relevance of these results to detoxification is emphasized.