A New Sensor for Determination of Paracetamol, Phenylephrine Hydrochloride and Chlorpheniramine Maleate in Pharmaceutical Samples Using Nickel Phosphate Nanoparticles Modified Carbon Past Electrode

A new chemically modified electrode was constructed based on nickel phosphate nanoparticles modified carbon paste electrode that immersed in NiCl2 solution (Ni-NP/CPE). The modified electrode was employed as a sensor for electrocatalytic oxidation of paracetamol (PAR), phenylephrine hydrochloride (PHE), chlorpheniramine maleate (CLP) in aqueous solutions using differential pulse voltammetry (DPV) method in Tris-HCl buffer solution with pH 7.0. The Ni(II) ion adsorbed in nickel phosphate nanoparticles can act as catalyst to oxidize above drugs. The prepared electrode showed voltammetric responses with high sensitivity and selectivity for PAR, PHE and CLP in optimal conditions, which makes it very suitable for determination of these compounds. A linear calibration graph was obtained with concentration ranges of 0.75–7.0, 0.02–10.0 and 0.05–10.0 mM for PAR, PHE and CLP, respectively. The detection limits of PAR, PHE and CLP were obtained 0.24, 0.0064 and 0.016 mM, respectively. The proposed method was successfully applied for determination of PAR, PHE and CLP in pharmaceutical samples.