Isocyanide-based three-component synthesis of 5-alkylimino-2,5-dihydrofuran-3,4- dicarboxylate derivatives

The zwitter ion formed from an alkyl isocyanide and dialkyl acetylenedicarboxylate reacts with Phenacyl bromide or its derivatives to form 5-alkylimino-2,5-dihydrofuran-3,4-dicarboxylate in relatively good yields at room temperature under solventless conditions.