Computational Prediction and Analysis of Interaction of Silver Nitrate with Chitinase Enzyme

Silver nitrate is an inorganic compound with chemical formula AgNO3. Silver or silver ions have long been used in many areas due to their strong antimicrobial activity against pathogenic microbes such as bacteria, yeast, fungi and algae. Trichoderma spp. are considered as biocontrol and growth promoting agents for many crop plants due to their antagonistic properties against plant pathogens. We, in this study, checked the possible interaction between silver nitrate and Chitinase enzyme. We used Molegro virtual docker (MVD). The results obtained from docking showed us that the best pose which is derived from MolDock score for Chitinase was -49.1418 with reranking score equal to -58. 1719. It is concluded that silver nitrate and Chitinase have interaction. Obtained results showed that silver nitrate can be attached to Chitinase in Trichoderma fungi cells leading to deactivation the enzymes.